I-Nanotechnology ekulethweni kwezidakamizwa zamehlo: izixazululo ezincane zezinselele ezinkulu

I-Nanotechnology ingenise inkathi entsha ekulethweni kwezidakamizwa zamehlo, inikeza izixazululo ezincane kodwa ezinamandla zokunqoba izinselele ezibalulekile ekwelapheni izifo zamehlo.

Izici eziyingqayizivele zezinto ze-nanoscale zinika amandla ukuklanywa kwezinhlelo zokulethwa kwezidakamizwa ezingangena emigomeni ye-ocular, zithuthukise i-bioavailability yezidakamizwa, futhi zilethe ukwelashwa okuhlosiwe.

I-Nanotechnology

Indlela ethembisayo yokuthuthukisa ukuphepha nokusebenza kahle kokulethwa kwezidakamizwa zamehlo.
Enye yezinzuzo ezibalulekile zabathwali bezidakamizwa ezisekelwe ku-nanotechnology yikhono labo lokuvikela kanye nokusimamisa ama-ejenti okwelapha. Imithi ye-ocular ivamise ukuwohloka kanye nokungabi bikho kwe-bioavailability ephansi ngenxa yokuguquguquka koketshezi oludabukisayo kanye nomsebenzi we-enzymatic. Ama-nanocarriers, njengama-nanoparticles nama-liposomes, angakwazi ukufaka izidakamizwa, azivikele ekonakalisweni kwe-enzymatic futhi athuthukise ukuzinza kwawo ngesikhathi sokuthutha ukuya ezicutshini eziqondiwe. Lesi sakhiwo sibonakale siwusizo ikakhulukazi emithini engancibiliki kahle emanzini noma izimpilo ezifushane.
Ngaphezu kwalokho, ubukhulu obuncane be-nanocarriers buvumela ukuba bangene ngokuphumelelayo imingcele yamehlo. I-cornea, isibonelo, ibeka inselele enkulu ekulethweni kwezidakamizwa ngenxa yongqimba lwawo lwangaphandle lwe-lipophilic. Ama-nanoparticles anokuguqulwa okufanelekile kwendawo angawela i-cornea ngokuphumelelayo, okuvumela izidakamizwa ukuthi zifinyelele ekamelweni elingaphambili futhi ziqondise izicubu ezithile ze-ocular.

izinzuzo

I-Nanotechnology iphinde yasiza amasistimu okulethwa kwezidakamizwa akhishwa njalo emehlweni. Ngokulungisa kahle ukwakheka nokwakheka kwama-nanocarriers, abacwaningi bangaklama amasistimu akhulula izidakamizwa ngenani elilawulwayo, agcine amazinga okwelapha isikhathi eside. Le ndlela inenzuzo ikakhulukazi ezifweni zamehlo ezingapheli njenge-glaucoma kanye nokuphazamiseka kwe-retinal, lapho ukuphathwa kwezidakamizwa okuvamile kungase kube umthwalo ezigulini.
Ngaphezu kokuthuthukisa ukulethwa kwezidakamizwa, i-nanotechnology inikeza amathuba okwelapha okuhlosiwe ku-ophthalmology. Ukusebenza kwe-nanocarriers ngama-ligand noma amasosha omzimba kunika amandla ukulethwa kwezidakamizwa eziqondene nesayithi. Lawa ma-ligand angakwazi ukubona ama-receptors athile noma ama-antigen akhona ezicutshini ze-ocular ezigulayo, aqinisekise ukuthi umuthi ufinyelela okuhlosiwe okuhlosiwe ngokunemba okuphezulu. Ama-nanocarriers ahlosiwe anesithembiso esikhulu ekwelapheni izimo ezifana nezimila zamehlo kanye nokuphazamiseka kwemithambo yegazi, lapho ukwelashwa kwendawo kuyisihluthulelo.

Izinselele

Nakuba i-nanotechnology ekulethweni kwezidakamizwa zamehlo inamandla amakhulu, izinselele zisekhona, ikakhulukazi mayelana nokuphepha kwesikhathi eside nokugunyazwa ngokomthetho. Ucwaningo oluqhubekayo luhlose ukubhekana nokukhathazeka okuhlobene ne-biocompatibility, ubuthi kanye nokuqedwa kwama-nanocarriers. Ngaphezu kwalokho, ukusebenzisana phakathi kwezemfundo, izimboni kanye nezindikimba ezilawulayo kubalulekile ukuze kusheshiswe ukuhunyushwa kwemithi yokwelapha ye-ocular esekelwe ku-nanotechnology kusukela elabhorethri kuya ekusebenzeni komtholampilo.
Sengiphetha, i-nanotechnology yethule izixazululo ezintsha nezisebenzayo ezinseleleni zokulethwa kwezidakamizwa zamehlo. Kusukela ekuthuthukiseni ukuzinza kwezidakamizwa kanye nokuba khona kwe-bioavailability kuya ekunikeni amandla izindlela zokwelapha eziqondiswe neziqhubekayo, i-nanotechnology isilungele ukuguqula ukwelashwa kwezifo zamehlo. Ukuthuthuka okuqhubekayo kulo mkhakha ngokungangabazeki kuzoholela ekulethweni kwezidakamizwa zamehlo okuphephile nokusebenza kahle, okuthuthukisa izinga lempilo yeziguli ezingenakubalwa emhlabeni jikelele.

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