I-BOC Sciences Yethula I-XDC Bioconjugation Platform ukuze Kuthuthukiswe Ucwaningo Lwezinto Eziphilayo

I-BOC Sciences, umhlinzeki oholayo wamakhemikhali ocwaningo kanye nezinsizakalo ezenziwe ngokwezifiso, yembula inkundla yayo entsha ye-XDC bioconjugation, ehlinzeka ngethuluzi elinengqondo lokulethwa kwezidakamizwa.

Iplathifomu entsha ye-XDC bioconjugation ehlinzekwa yi-BOC Sciences yethula uhla lobuchwepheshe obuthuthukisiwe nezivumelwano ezenziwe kahle, iguqula inqubo yokuxhumanisa izinhlanganisela nama-biomolecules.

Ngokusebenzisa izindlela zokuhlanganisa ezisezingeni eliphezulu, eziqondiswe kuzixazululo zokulethwa kwezidakamizwa kanye nezinhlelo zokulethwa kwe-RNAi, ososayensi bangathola ukulawula okungakaze kubonwe ekwakhiweni nasekuhlanganiseni ama-bioconjugates.

Izindlela Zokuhlanganisa Izindlela zokuhlanganisa zendabuko ze-bioconjugation zinezihibe ezithile, ezifana nobuthi obungaqondiwe, ukuncipha kokuqina kokuhlangana, kanye nokulahlekelwa okungaba khona komsebenzi webhayoloji. Ukubhekana nale mikhawulo, iplathifomu ye-BOC Sciences XDC bioconjugation isebenzisa izindlela ezahlukahlukene zokuhlanganisa indawo ethile, okuhlanganisa ukufakwa kwe-amino acid engeyona eyemvelo, ukuhlanganiswa kwe-cysteine ​​​​onjiniyela, i-enzyme-assisted ligation, ukulungiswa kabusha kwe-glycan, kanye nokukhiqizwa kwe-glycocojugation.

Iqondisa Ukulethwa Kwezidakamizwa, inkundla ye-XDC bioconjugation iphinde inikeze amasu aphelele okukhomba avumela ukulethwa kwezidakamizwa ngqo endaweni oyifunayo. Ukuthatha ama-conjugates ezidakamizwa ezilwa nezidakamizwa, isihloko esivame ukufundwa sama-XDC, njengesibonelo, i-BOC Sciences ithuthukise izindlela zamakhemikhali noma ze-enzymatic noma inhlanganisela yakho ukuze iguqule ngokunembile ama-amino acid athile ukuze kukhiqizwe ama-ADC anomthwalo onembile wezidakamizwa nezizinda ezinamathiselwe ezilungiselelwe kusengaphambili.defikuqedwe futhi kuhloliwe.

Ukuletha ama-molecule ahlosiwe aphelele, ochwepheshe be-BOC Sciences kufanele bacabangele izici ezihlanganisa ukusebenza kahle, amandla okungena kumaseli, ukuphendula okungaba khona kwamasosha omzimba, usayizi wamangqamuzana, ubulula bokuhlanganisa, kanye nezindleko. Ilandela le mihlahlandlela, inkundla yayo ye-XDC manje isiyakwazi ukukhiqiza izithwali zemithi ezisezingeni eliphezulu, ezihlanganisa amasosha omzimba, izingcezu ze-antibody, ama-peptides nama-oligonucleotide. Ukulethwa kwe-RNAi Okunye okuphawulekayo ukuthi inkundla ye-XDC inikeza indlela ethembisayo yokuthuthukisa ukulethwa kwezidakamizwa ezihlosiwe ezingaphakathi kweseli ngokuguqulwa kwamakhemikhali ama-siRNA ukuze kwakhe ama-conjugate.

XDC bioconjugation platform

Lawa ma-conjugate we-siRNA afana nama-conjugates e-GalNAc-siRNA kanye nama-antibody-siRNA conjugates abe nezici ezithuthukisiwe ngokuya nge-pharmacokinetics, ukutholwa kwamaselula, ukucaciswa okuhlosiwe, nokuphepha. UDkt. Carrie Taylor, umkhulumeli we-BOC Sciences, ugqamise ukubaluleka kwale nkundla ye-XDC bioconjugation. Uthe: “Ubuchwepheshe bethu obuhamba phambili buhlose ukubhekana nezinselelo ezibhekene nososayensi emkhakheni we-bioconjugation. Ngokunciphisa ubuthi obungahlosiwe nokuthuthukisa ukuzinza kokuhlanganisa, sikholelwa ukuthi inkundla ye-XDC bioconjugation izobamba iqhaza kakhulu ekuthuthukisweni kwemithi esebenza kahle kakhulu ye-biopharmaceuticals kanye namathuluzi okuxilonga.” Ngokukhishwa kweplathifomu ye-XDC bioconjugation, i-BOC Sciences iqinisekisa ukuzibophezela kwayo ekukhuthazeni ukuqamba okusha kanye nokunika abacwaningi amandla ekuphishekeleni kwabo impumelelo kusayensi ye-biomedical. "Manje konke sekumi ngomumo ukuhlangabezana nezidingo ezahlukene ze-bioconjugation zabacwaningi," kusho okhulumela ososayensi etshela ososayensi.

Isayensi ye-BOC

I-BOC Sciences ingumhlinzeki wase-US wamakhemikhali ocwaningo (i-bio) kanye nezinsizakalo ze-bioconjugation. Ithimba layo lochwepheshe lizibophezele ekukhuthazeni inqubekelaphambili yesayensi ngokusebenzisa ubuchwepheshe obusha kanye nokwenza abacwaningi bakwazi ukuvula amathuba amasha ekuthuthukisweni kwemithi.

Lina Green