SIFI, kambani inotungamira yemishonga mukuvandudza zvigadziriso zvekurapa kwezvirwere zvemaziso, anofara kuzivisa kutangwa kweEpiColin, rutsigiro rwakakwana rwevarwere veglaucoma. Mushure meAmiriox naEcbirio, hypotonizing zvinodhaka zvakadzoserwa zvizere neNHS, EpiColin ndiyo yechitatu innovation munharaunda yeglaucoma therapeutic yakaunzwa neSIFI muhafu yechipiri ya2022.
EpiColin ari dhayeti yekuwedzera zvichibva pazvinomera zveColeus forskohlii uye girini tii, ine citicoline, homotaurine, mavhitaminzi eboka B uye vhitamini E, chinhu chakakosha chekuwedzera kune hypotonizing kurapa kwekutarisira glaucoma, chirwere chisingaperi chinokanganisa.
"Iko zvino zvave kuzivikanwa kuti dzvinyiriro yeziso handiyo yega inokonzera glaucoma." akadaro Dr. Matteo Sacchi, Musoro weGlaucoma Center yeUniversity Eye Clinic, San Giuseppe Hospital -IRCS MultiMedica, Milan, pamwe chete nekongiresi yenyika ichangoburwa yakatsaurirwa glaucoma, "Kuwedzera kutarisisa iko zvino kwakaiswawo pazvinhu zvakaita seoxidative stress, neuroinflammation uye mitochondrial dysfunction, zvichisimbisa kukosha kweiyo synergistic nzira yekurapa iyo inosanganisira pfupi-uye yenguva refu yekuona yemurwere."
Muvarwere vane glaucoma, chirwere ichi chinogona kufambira mberi kunyangwe kudzikiswa kwemukati memaziso1-3, uye saka zvakakosha kutsigira kurapa kudzivirira kana kunonoka iyi retinal cell degenerative process4,5. Iyo yakakwana EpiColin yekurapa yekuwedzera yakagadzirirwa kuburitsa yakakosha neuroprotective uye antioxidant mhedzisiro nekuda kwe synergistic chiito chega chega zvikamu, zvinozivikanwa uye zvakavimbika, mukutsigira hypotonizing therapy. Iyo neuroprotective mhedzisiro yenutraceuticals yakaratidzwa zvese mu preclinical in vitro uye mu vivo zvidzidzo, uye muzvidzidzo zvekiriniki.6.
Zvinoenderana nefungidziro ichangoburwa muItari kune vangangoita 550.000 vakasimbiswa varwere vane glaucoma ine chiitiko chinowedzera nezera, zvichikanganisa vanopfuura 10% yevadzidzi vanopfuura makore makumi manomwe. Zvinofungidzirwa kuti mumakore makumi maviri anotevera kuchave ne70% kuwedzera kwenyaya dzakasimbiswa muItari nepamusoro pe20% mumatunhu anotarisirwa kuchembera zvakanyanya.7.
Glaucoma chirwere chemaziso chinowanzoenderana nekudzvinyirira kwakanyanya muziso. Sekureva kweWHO, vanhu vanosvika mamirioni makumi matanhatu vari kubatwa pasi rose8. Ndicho chikonzero chechipiri chekupofumadza pasi rose mushure mechirwere chegomarara, asi ndicho chekutanga chisingachinjike9.
AMIRIOX™ uye ECBIRIO™ Amiriox™ (bimatoprost 0,3 mg/ml) uye Ecbirio™ (bimatoprost 0,3 mg/ml + timolol 5 mg/ml) ndiwo, zvichiteerana, iyo itsva monotherapy uye yakagadziriswa madonhwe emaziso anotenderwa kuderedzwa kweakakwirisa intraocular pressure in chronic open-angle. varwere vane glaucoma uye ocular hypertension. Amiriox ™ uye Ecbirio ™ inowanikwa mune yakawanda dose preservative-yemahara magadzirirwo anochengetedza ocular pamusoro, inoshanda kwemwedzi mitatu mushure mekuvhurwa.
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