Osteogenesis Imperfecta is commonly known as brittle bone disease. In severe cases, multiple fractures are common, while a milder case involves a few fractures or broken bones in a person's lifetime. People with this condition are born unable to produce connective tissue or have it due to faulty genes. It impacts the synthesis of collagen, the connective tissue protein that strengthens bones. The disease occurs in forms I and IX, with I being mild and IX being fatal. The main sign of osteogenesis imperfecta is frequent fractures. Other symptoms include loose joints, deformed bones, hearing loss, breathing problems and dental problems. Osteogenesis imperfecta can be confirmed through DNA or collagen testing.
There is no treatment for this because it is a genetic condition. Exercise and quitting smoking are two examples of healthy lifestyle choices that can help prevent fractures. Braces, painkillers, and proper care of bone fractures are all helpful. Antibiotics and antiseptics can be used to treat bone infections. Increasing demand for new therapies for the treatment of osteogenesis imperfecta and licensing agreements and strategic collaborations by key industry players for treatment development are expected to propel the growth of the global osteogenesis imperfecta treatment market in forecast period.
Increasing research and development funding to develop new treatments and therapies is an important factor spurring the growth of the global osteogenesis imperfecta treatment market. Furthermore, licensing agreements and strategic collaborations by major industry players for the development of OI treatment are another factor driving the growth of the market. Furthermore, osteogenesis imperfecta is a genetic disease, and the family history of people with OI is causing an increase in the number of cases worldwide, which is expected to drive market growth.
For example, in May 2021, Mereo BioPharma Group plc announced encouraging 6-month data from its Phase II-B clinical trial in adult patients with osteogenesis imperfecta type IV, III or I treated with setursumab (BPS-804). The European Medicines Agency (EMA) had approved the company's pediatric investigation plan for BPS-804 and with a registration study design, and the drug candidate is now ready for Phase III for a pediatric population.
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