Biognosys, a leading inventor and developer of mass spectrometry (MS)-based proteomics solutions, today announced its participation in the Human Proteome Organization (HUPO) World Congress from September 17 to 21 in Busan, South Korea.
During the Technology Advancements session on Tuesday, September 19, Dr. Lukas Reiter, Chief Technology Officer at Biognosys, will give a “Bottom-up Proteomics using DIA” presentation on the evolution, recent developments, and future of data-independent acquisition (DIA). in MS-based proteomics. Biognosys will also present ten posters showcasing technological innovations and new scientific data with its proprietary proteomics services, software and research kits. Biognosys' team of scientific experts will exhibit and offer demos of the software at booth no. 408.
Bruker, a strategic partner of Biognosys, will introduce new concepts for the timsTOF platform and the Bruker ProteoScape™ software suite, creating synergies with the Spectronaut software ® and Biognosys' iRT Kit to offer customers advanced capabilities for high-fidelity, high-throughput proteomics.
“I am excited to present significant advances with Biognosys' MS proteomics technology and solutions that bring us once again closer to making the proteome truly usable for research, drug development and clinical decision making,” commented the Dr. Lukas Reiter . “Our continuously improving software and proven kits enable users of leading MS instruments to run state-of-the-art, seamless workflows for deep, high-throughput, internally reproducible proteomics research. Our CRO services provide biopharmaceutical and diagnostics customers with unprecedented precision and insights to accelerate biomarker discovery and drug development.”
Spectronaut 18, the latest version of Biognosys' flagship software, offers significantly further improved identification rate and quantification quality, as well as various new features that make DIA proteomics more efficient and scalable. At HUPO, Biognosys will present three posters highlighting the powerful applications of Spectronaut 18 for comprehensive proteome quantification. Notable innovations include the use of directDIA+™ for faster, library-free analysis and the deep learning with DeepQuant to improve the quantification of low abundant proteins through a neural network for interference correction of precursor quantities.
Biognosys will present three posters illustrating biomarker discovery and drug development research conducted with esteemed collaborators, including Genmab, Johns Hopkins University School of Medicine, Stanford University, and the University of Zurich. The studies used Biognosys' TrueDiscovery platform for unbiased proteomics and collectively demonstrate the quantitative precision, robustness, and broad applicability of MS proteomics for oncology and neuroscience research. A fourth poster evaluates the technological and biological complementarity of TrueDiscovery and the Olink affinity-based platform ® Explore by Olink Proteomics AB for plasma proteomics.
Biognosys' TrueTarget platform leverages limited proteolysis mass spectrometry (LiP-MS) to facilitate the identification and validation of drug targets. An initial poster, in collaboration with InterAx, demonstrates TrueTarget's unique capabilities in deconvoluting the target of a G protein-coupled receptor (GPCR) antagonist, mapping its binding sites and providing structural insights into the mechanism of action. A second poster, in collaboration with Samsara Therapeutics, illustrates how target deconvolution with TrueTarget, followed by unbiased proteome profiling with TrueDiscovery, enabled efficient identification and validation of target proteins and improved understanding of biological systems in a new therapeutic development.
To ensure optimal MS performance, Bruker introduces TwinScape™, a digital twin for the timsTOF platform, interconnected with ProteoScape software to support real-time quality control (QC) with the Biognosys iRT kit. The peptides in the iRT kit have been carefully optimized for stability, sensitivity and retention time range and this iRT kit can now be used for system quality control in Bruker's ProteoScape proteomics software. Biognosys Business Development Manager – Products, Dr. Sira Echevarria, will present how Spectronaut offers improved library-free proteomic analysis for dia-PASEF using directDIA+ during Bruker's HUPO lunch seminar on Tuesday, September 19.
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