Ngokwemveli, imibhobho eyenziwe ngesandla yayiyeyona ndlela iphambili eyayisetyenziswa kwi-HTS, kodwa yayinobunzima kwaye inempazamo, iyenza ingafaneleki ukuphatha amakhulu okanye amawaka eisampulu. Njengoko imfuno yeendlela zokuhlola ezikhawulezayo nezithembekileyo zisanda, i-ALHS iye yavela njengesisombululo esifanelekileyo. Ezi zixhobo zerobhothi ezizenzekelayo ziyakwazi ukuphatha iisampuli ezininzi ngaxeshanye kwaye zenze ukuhanjiswa okuchanekileyo kwamanzi kunye ne-microliter okanye i-nanoliter echanekileyo.
Ukuzenzela imisebenzi yokuphatha ulwelo kwi-HTS kwandisa kakhulu imveliso. I-ALHS inokulungiselela ngokufanelekileyo ii-microplates kunye neekhompawundi zovavanyo, iisampuli zokulawula kunye nee-reagents, ukunciphisa ixesha elifunekayo ukuseta imifuniselo. Ukongeza, banokwenza i-serial dilution, evumela abaphandi ukuba bavavanye ngaxeshanye uluhlu olubanzi lokugxila. Ngenxa yoko, izazinzulu zinokujonga amawaka eesampuli okanye iikhompawundi kwiqhezu lexesha elifunekayo ngeendlela zezandla.
Isantya kunye nokusebenza kakuhle kwe-ALHS kwi-HTS iguqule uphando lwamayeza. Iinkampani ezixuba amayeza kunye namaziko ophando ngoku anokukhangela ngokukhawuleza amathala eencwadi amakhulu eekhemikhali ngokuchasene noko kujoliswe kuko kwibhayoloji, ngokukhawuleza ukuchonga abantu abanokuba ngamachiza. Oku kukhawuleziswa kumanqanaba okuqala ophuhliso lwamachiza kunesiphumo sokwehla, kukhawulezisa umbhobho wonke kwaye kuzise unyango olunokwenzeka kwizigulana ngokukhawuleza.
Kuphando lwe-genomic, ukuphatha ulwelo oluzenzekelayo ludlala indima ebalulekileyo ekuqhubeni iisampulu ze-DNA kunye ne-RNA. I-HTS ivumela abaphandi ukuba bahlalutye ukuchazwa kofuzo, bachonge ukwahluka kofuzo, kwaye benze izifundo ezinkulu ze-genomics ezisebenzayo. Ukuchaneka kwe-ALHS kuqinisekisa ukuba iisampulu zesampulu ziyahambelana, zinciphisa ukwahluka kunye nokuvelisa idatha ekumgangatho ophezulu kuhlalutyo olubanzi lwe-genomic.
Indima ye-ALHS kwi-HTS idlulela ngaphaya kokufunyanwa kweziyobisi kunye ne-genomics. Kwimimandla efana neproteomics, abaphandi banokwenza uvavanyo lweprotheyini enkulu, ukuququzelela ukuchongwa kwezinto ezinokuthi zibe khona kunye neethagethi zonyango. Ngaphaya koko, ukuphathwa kolwelo okuzenzekelayo kuvumela uhlalutyo olusekwe kwiseli ephezulu, igalelo kwinkqubela phambili kwibhayoloji yeeseli kunye neyeza lomntu.
Njengoko imfuno yeendlela zokuhlola ezisebenzayo nezingabizi kakhulu zikhula, ikamva le-ALHS kwi-HTS libonakala lithembisa. Inkqubela phambili yezobuchwephesha kusenokwenzeka ukuba ikhokelele kwiinkqubo ezintsonkothileyo, ezidityanisiweyo ezinxibelelana ngokungenamthungo nezinye izixhobo zelabhoratri. Ngaphezu koko, ukuhlanganiswa kwee-algorithms ingqiqo e yokufunda umatshini inokwandisa ngakumbi iiprothokholi zokuhlola, ukwenza uhlalutyo lwedatha lukhawuleze kwaye luchaneke ngakumbi.
Ukuqukumbela, iisistim zokuphatha ulwelo oluzenzekelayo ziye zaba zizixhobo eziyimfuneko zokukhawulezisa ukufunyanwa ngovavanyo oluphezulu. Ngokwenza kube lula ukulawula iisampuli kunye neekhompawundi ngokuchanekileyo kunye nokusebenza kakuhle, i-ALHS yenza abaphandi bahlalutye iiseti zedatha enkulu kwaye baphonononge iindlela ezintsha zophando. Njengoko itekhnoloji iqhubela phambili, ezi nkqubo zizenzelayo ziya kuqhubeka ziqhuba inkqubela phambili yezenzululwazi, zikhuthaza ukuqamba izinto ezintsha kunye nokutyhala imida yolwazi kuzo zonke iinkalo zenzululwazi.
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